\u3000\u6b6f\u830e\u3068\u6b6f\u306e\u5065\u5eb7\u306f\u8133\u306e\u5065\u5eb7\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3002\u53e3\u5185\u306e\u708e\u75c7\u7269\u8cea\u3068\u53e3\u8154\u5fae\u751f\u7269(\u30d0\u30af\u30c6\u30ea\u30a2)\u304c\u640d\u50b7\u3057\u305f\u6b6f\u830e\u306e\u8840\u7ba1\u58c1\u3092\u7a81\u304d\u7834\u308a\u5165\u3063\u305f\u5f8c\u3001\u8840\u6d41\u306b\u4e57\u3063\u3066\u8133\u8840\u7ba1\u306b\u307e\u3067\u6d41\u308c\u308b\u304b\u3089\u3060\u3002\u4f8b\u3048\u3070\u3001\u6b6f\u5468\u708e\u3068\u95a2\u9023\u3057\u305f\u708e\u75c7\u7269\u8cea\u3084\u53e3\u8154\u5fae\u751f\u7269\u306f\u3001\u8133\u8840\u7ba1\u306e\u708e\u75c7\u3092\u8a98\u767a\u3057\u305f\u308a\u60aa\u5316\u3055\u305b\u3001\u8133\u5352\u4e2d\u30fb\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u30fb\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u304b\u306d\u306a\u3044\u3002\u3067\u306f\u3001\u53e3\u8154\u5fae\u751f\u7269\u3092\u901a\u3058\u3066\u8a8d\u77e5\u75c7\u306e\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3067\u304d\u308b\u3060\u308d\u3046\u304b?<\/p>\n
\u3000\u82f1\u56fd\u30a8\u30af\u30bb\u30bf\u30fc\u5927\u5b66\u306e\u7814\u7a76\u9663\u304c50\u6b73\u4ee5\u4e0a\u306e\u6210\u4eba115\u4eba\u306e\u553e\u6db2\u304b\u3089\u8133\u306e\u5065\u5eb7\u3001\u7279\u306b\u8133\u306e\u8a8d\u77e5\u529b\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53e3\u8154\u5fae\u751f\u7269\u3092\u78ba\u8a8d\u3057\u3001\u56fd\u969b\u5b66\u8853\u8a8c\u300c\u56fd\u7acb\u79d1\u5b66\u9662\u4f1a\u5831(PNAS)Nexus\u300d\u306b\u767a\u8868\u3057\u305f\u3002\u5b9f\u9a13\u53c2\u52a0\u8005\u306e52%\u306f\u8133\u306e\u8a8d\u77e5\u529b\u306b\u7570\u5e38\u304c\u306a\u304f\u300148%\u306f\u8a18\u61b6\u529b\u3092\u542b\u3081\u3066\u8efd\u5fae\u306a\u8a8d\u77e5\u969c\u5bb3(MCI)\u3092\u60a3\u3063\u3066\u3044\u305f\u3002<\/p>\n
\u3000\u7814\u7a76\u9663\u306f\u3001\u5f7c\u3089\u306e\u553e\u6db2\u3092\u5206\u6790\u3057\u305f\u7d50\u679c\u3001\u30cd\u30a4\u30bb\u30ea\u30a2(Neisseria)\u3068\u30d8\u30e2\u30d5\u30a3\u30eb\u30b9(Haemophilus)\u3068\u3044\u3046\u4e8c\u3064\u306e\u5fae\u751f\u7269\u30b0\u30eb\u30fc\u30d7\u304c\u3001\u3088\u308a\u826f\u3044\u8133\u306e\u5065\u5eb7\u3068\u95a2\u9023\u304c\u3042\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u305f\u3002\u3053\u306e\u53e3\u8154\u30d0\u30af\u30c6\u30ea\u30a2\u3092\u6301\u3064\u4eba\u3005\u306f\u3001\u8133\u306e\u8a8d\u77e5\u529b\u691c\u67fb\u3067\u3088\u308a\u826f\u3044\u70b9\u6570\u3092\u793a\u3057\u305f\u3002\u7279\u306b\u8a18\u61b6\u529b\u3068\u6ce8\u610f\u529b\u3001\u8907\u96d1\u306a\u4f5c\u696d\u3092\u9042\u884c\u3059\u308b\u80fd\u529b\u304c\u9ad8\u304b\u3063\u305f\u3002\u5f7c\u3089\u306e\u553e\u6db2\u304b\u3089\u306f\u307e\u305f\u4e9c\u785d\u9178\u5869\u30a4\u30aa\u30f3\u306e\u6570\u5024\u304c\u3088\u308a\u9ad8\u304f\u51fa\u305f\u3002\u4e9c\u785d\u9178\u5869\u306f\u30d0\u30af\u30c6\u30ea\u30a2\u304c\u91ce\u83dc\u306b\u542b\u307e\u308c\u305f\u785d\u9178\u5869\u3092\u5206\u89e3\u3059\u308b\u6642\u306b\u751f\u6210\u3055\u308c\u308b\u7269\u8cea\u3060\u3002<\/p>\n
\u3000\u53e3\u8154\u30d0\u30af\u30c6\u30ea\u30a2\u306f\u3001\u4e9c\u785d\u9178\u5869\u306e\u5206\u89e3\u3092\u901a\u3058\u3066\u4e00\u9178\u5316\u7a92\u7d20\u3092\u751f\u6210\u3059\u308b\u3053\u3068\u3067\u3001\u8840\u6db2\u5faa\u74b0\u3092\u3088\u308a\u5186\u6ed1\u306b\u3057\u3001\u8840\u5727\u3092\u4e0b\u3052\u308b\u306e\u306b\u5f79\u7acb\u3064\u3002\u7814\u7a76\u9663\u306f\u300c\u3053\u308c\u306f\u30db\u30a6\u30ec\u30f3\u8349\u306e\u3088\u3046\u306b\u785d\u9178\u5869\u304c\u8c4a\u5bcc\u306a\u91ce\u83dc\u3092\u6442\u53d6\u3059\u308c\u3070\u5065\u5eb7\u306a\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u6570\u5024\u3092\u9ad8\u3081\u3001\u8133\u306e\u5065\u5eb7\u306b\u5f79\u7acb\u3064\u3068\u3044\u3046\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u300d\u3068\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n
\u3000\u7814\u7a76\u9663\u306f\u3001\u4eca\u56de\u306e\u7814\u7a76\u306e\u5f8c\u7d9a\u3068\u3057\u3066\u785d\u9178\u5869\u3068\u8c4a\u5bcc\u306a\u30d3\u30fc\u30c8\u30b8\u30e5\u30fc\u30b9\u304c\u53e3\u8154\u30d0\u30af\u30c6\u30ea\u30a2\u3092\u901a\u3058\u3066\u8133\u6a5f\u80fd\u306b\u826f\u3044\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3092\u8abf\u3079\u3066\u3044\u308b\u3068\u4ed8\u3051\u52a0\u3048\u305f\u3002<\/p>\n
\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u8a8d\u77e5\u75c7\u4e88\u9632\u306e\u7cf8\u53e3\u306b\u306a\u308b\u304b\u3082<\/p>\n
\u3000\u4e00\u65b9\u3001\u8133\u306e\u5065\u5eb7\u306b\u6709\u5bb3\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3068\u307f\u3089\u308c\u308b\u53e3\u8154\u30d0\u30af\u30c6\u30ea\u30a2\u3082\u767a\u898b\u3055\u308c\u305f\u3002\u8a18\u61b6\u529b\u306b\u554f\u984c\u3092\u793a\u3057\u305f\u4eba\u3005\u304b\u3089\u306f\u3001\u4e00\u822c\u7684\u306b\u6b6f\u830e\u306e\u75be\u60a3\u3068\u95a2\u9023\u306e\u3042\u308b\u300c\u30dd\u30eb\u30d5\u30a3\u30ed\u30e2\u30ca\u30b9(Porphyromonas)\u300d\u3068\u3044\u3046\u30d0\u30af\u30c6\u30ea\u30a2\u304c\u3088\u308a\u591a\u304f\u767a\u898b\u3055\u308c\u305f\u3002<\/p>\n
\u3000\u7814\u7a76\u9663\u306f\u307e\u305f\u3001\u4e9c\u785d\u9178\u5869\u306e\u6570\u5024\u304c\u4f4e\u3044\u4eba\u3005\u304b\u3089\u591a\u304f\u767a\u898b\u3055\u308c\u305f\u30d7\u30ec\u30dc\u30c6\u30e9(Prevotella)\u3068\u3044\u3046\u30d0\u30af\u30c6\u30ea\u30a2\u3082\u8133\u306e\u8a8d\u77e5\u529b\u4f4e\u4e0b\u3068\u95a2\u9023\u304c\u3042\u308b\u3068\u898b\u3089\u308c\u308b\u3068\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u5371\u967a\u907a\u4f1d\u5b50\u3067\u3042\u308b\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE4(APOE4)\u3092\u4fdd\u6709\u3057\u3066\u3044\u308b\u4eba\u3005\u306e\u30d7\u30ec\u30dc\u30c6\u30e9\u6570\u5024\u304c\u3055\u3089\u306b\u9ad8\u3044\u50be\u5411\u3092\u793a\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u76f4\u63a5\u7684\u306a\u56e0\u679c\u95a2\u4fc2\u306f\u660e\u3089\u304b\u306b\u3055\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n
\u3000\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u8a8d\u77e5\u75c7\u3068\u53e3\u8154\u5065\u5eb7\u306e\u95a2\u9023\u6027\u3092\u793a\u5506\u3059\u308b\u6700\u8fd1\u306e\u8272\u3005\u306a\u7814\u7a76\u3068\u8108\u3092\u5171\u306b\u3059\u308b\u3002\u4f8b\u3048\u3070\u65e5\u672c\u306e\u6771\u5317\u5927\u5b66\u306e\u7814\u7a76\u9663\u306f\u3001\u6b6f\u830e\u306e\u75be\u60a3\u3068\u8a18\u61b6\u5316\u5b66\u7fd2\u306b\u6838\u5fc3\u7684\u5f79\u5272\u3092\u3059\u308b\u6d77\u99ac\u306e\u4f53\u7a4d\u7e2e\u5c0f\u304c\u4e92\u3044\u306b\u95a2\u9023\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u78ba\u8a8d\u3057\u3001\u7c73\u56fd\u30eb\u30a4\u30d3\u30eb\u5927\u5b66\u306e\u7814\u7a76\u9663\u306f\u3001\u6b7b\u4ea1\u3057\u305f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u60a3\u8005\u306e\u8133\u304b\u3089\u6b6f\u830e\u306e\u75be\u60a3\u306e\u75c5\u539f\u83cc\u3067\u3042\u308b\u30dd\u30eb\u30d4\u30ed\u30e2\u30ca\u30b9\u3092\u767a\u898b\u3057\u305f\u3002\u30cd\u30ba\u30df\u3092\u5bfe\u8c61\u306b\u3057\u305f\u5b9f\u9a13\u3067\u306f\u3001\u3053\u306e\u30d0\u30af\u30c6\u30ea\u30a2\u306b\u611f\u67d3\u3057\u305f\u30cd\u30ba\u30df\u306e\u8133\u304b\u3089\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u305f\u3093\u3071\u304f\u8cea\u3067\u3042\u308b\u30a2\u30df\u30ed\u30a4\u30c9\u30d9\u30fc\u30bf\u304c\u3055\u3089\u306b\u591a\u304f\u691c\u51fa\u3055\u308c\u305f\u3002<\/p>\n
\u785d\u9178\u5869\u304c\u8c4a\u5bcc\u306a\u8449\u91ce\u83dc\u306e\u6442\u53d6\u3067\u826f\u3044\u5fae\u751f\u7269\u3092\u5897\u3084\u3059<\/p>\n
\u3000\u7814\u7a76\u9663\u306f\u300c\u4eca\u56de\u306e\u7814\u7a76\u306f\u8133\u306e\u5065\u5eb7\u7814\u7a76\u306b\u304a\u3044\u3066\u5927\u304d\u306a\u610f\u5473\u304c\u3042\u308b\u300d\u3068\u3057\u3066\u3001\u8133\u306e\u5065\u5eb7\u3092\u652f\u63f4\u3057\u305f\u308a\u5bb3\u3057\u305f\u308a\u3059\u308b\u30d0\u30af\u30c6\u30ea\u30a2\u304c\u5225\u306b\u3042\u308b\u306a\u3089\u3070\u3001\u53e3\u8154\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u751f\u614b\u7cfb\u3092\u5909\u3048\u308b\u6cbb\u7642\u6cd5\u304c\u8a8d\u77e5\u75c7\u4e88\u9632\u7b56\u306e\u4e00\u3064\u306b\u306a\u308a\u3046\u308b\u3068\u671f\u5f85\u3057\u305f\u3002\u4f8b\u3048\u3070\u3001\u30cd\u30a4\u30bb\u30ea\u30a2\u306e\u3088\u3046\u306a\u4e9c\u785d\u9178\u5869\u751f\u6210\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u6210\u9577\u3092\u4fc3\u9032\u3057\u3001\u30d7\u30ec\u30dc\u30c6\u30e9\u3068\u30dd\u30eb\u30d4\u30ed\u30e2\u30ca\u30b9\u306e\u500b\u4f53\u6570\u3092\u6e1b\u3089\u305b\u3070\u3001\u8001\u5316\u306b\u3088\u308b\u8133\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u6291\u5236\u3059\u308b\u306e\u306b\u5f79\u7acb\u3064\u3068\u3044\u3046\u3053\u3068\u3060\u3002<\/p>\n
\u3000\u7814\u7a76\u9663\u306f\u307e\u305f\u3001\u300c\u3053\u306e\u3088\u3046\u306a\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u6570\u5024\u3092\u6e2c\u5b9a\u3059\u308b\u691c\u67fb\u3092\u5c06\u6765\u306b\u6b6f\u79d1\u691c\u8a3a\u306e\u4e00\u90e8\u3068\u3057\u3066\u5c0e\u5165\u3057\u3001\u8133\u306e\u5065\u5eb7\u4f4e\u4e0b\u306e\u5146\u5019\u3092\u521d\u671f\u306b\u611f\u77e5\u3059\u308b\u3053\u3068\u3082\u8003\u3048\u3089\u308c\u308b\u3060\u308d\u3046\u300d\u3068\u4ed8\u3051\u52a0\u3048\u305f\u3002<\/p>\n
\u3000\u7814\u7a76\u3092\u4e3b\u5c0e\u3057\u305f\u30b8\u30e7\u30a2\u30f3\u30ca\u30fb\u30ec\u30d5\u30eb\u535a\u58eb\u5f8c\u7814\u7a76\u54e1(\u5206\u5b50\u751f\u7269\u5b66)\u306f\u300c\u30b6\u30fb\u30ab\u30f3\u30d0\u30bb\u30fc\u30b7\u30e7\u30f3\u300d\u306b\u5bc4\u7a3f\u3057\u305f\u6587\u3067\u300c\u4eca\u5f8c\u3001\u53e3\u8154\u5fae\u751f\u7269\u7fa4\u96c6\u304c\u8133\u306e\u5065\u5eb7\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u308c\u3070\u3001\u53e3\u8154\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u7ba1\u7406\u3092\u901a\u3058\u3066\u8a8d\u77e5\u75c7\u3092\u65e9\u671f\u306b\u767a\u898b\u3057\u9045\u5ef6\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u65b0\u3057\u3044\u53ef\u80fd\u6027\u304c\u958b\u304b\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u3046\u308b\u300d\u3068\u3057\u300c\u305d\u308c\u307e\u3067\u6700\u3082\u826f\u3044\u65b9\u6cd5\u306f\u6b6f\u3092\u6e05\u6f54\u306b\u7ba1\u7406\u3057\u3001\u8449\u304c\u591a\u3044\u7dd1\u8272\u91ce\u83dc\u306e\u3088\u3046\u306b\u785d\u9178\u5869\u304c\u8c4a\u5bcc\u306a\u98df\u54c1\u3092\u6442\u53d6\u3057\u3066\u53e3\u5185\u306b\u826f\u3044\u30d0\u30af\u30c6\u30ea\u30a2\u3092\u5897\u3084\u3059\u3053\u3068\u300d\u3068\u8a71\u3057\u305f\u3002<\/p>\n
*\u8ad6\u6587\u60c5\u5831<\/p>\n
\u3000Oral microbiome and nitric oxide biomarkers in older people with mild cognitive impairment and APOE4 genotype\u3002<\/p>\n
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